Histone Demethylase Inhibitor

Histone Demethylase Inhibitors (84):

Cat. No.	Product Name	Effect	Purity

HY-12782T

Iadademstat dihydrochloride	Inhibitor	99.98%
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.

HY-100546A

GSK-LSD1 dihydrochloride	Inhibitor	≥98.0%
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 16 nM.

HY-100760

Toxoflavin	Inhibitor	99.88%
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity.

HY-18632A

GSK2879552 dihydrochloride	Inhibitor	99.19%
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity.

HY-168433

LSD1/EGFR-IN-1	Inhibitor
LSD1/EGFR-IN-1 (compound L-1) is a potent inhibitor of LSD1, EGFR^T790M/L858R and EGFR^{L858R/T790M/C797S}, with IC₅₀s of 6.24 and 2.06 and 5.01 μM, respectively. LSD1/EGFR-IN-1 plays an important role in cancer research.

HY-111048

Corin	Inhibitor	98.16%
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a K_i(inact) of 110 nM for LSD1 and an IC₅₀ of 147 nM for HDAC1.

HY-139782

SKLB325	Inhibitor	99.23%
SKLB325 is a Jumonji domain-containing 6 (JMJD6) inhibitor with a binding affinity (K_D) value of 0.755?μM, and the IC₅₀ value of 0.7797?μM. SKLB325 exhibits antitumor effects on ovarian cancer in vivo and in vitro. SKLB325 induces apoptosis. SKLB325 exhibits remarkable antitumor efficacy in renal cell carcinoma (RCC) .

HY-109169A

Bomedemstat ditosylate	Inhibitor	99.17%
Bomedemstat (IMG-7289) ditosylate is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis.

HY-Q36392

JNJ-9350	Inhibitor	99.21%
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC₅₀ value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC₅₀ value of 0.79 μM. JNJ-9350 can be used for the research of cancer.

HY-12315

N-Oxalylglycine	Inhibitor	99.28%
N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC₅₀ of 2.1 μM and 5.6 μM, respectively.

HY-112623

Vafidemstat	Inhibitor	99.53%
Vafidemstat (ORY-2001) is an oral, brain penetrant, dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.

HY-W017132

2,4-PDCA	Inhibitor	99.80%
2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics.

HY-162275

JMJD1C-IN-1	Inhibitor	99.99%
JMJD1C-IN-1 (compound 193D7) is an inhibitor of JMJD1C with oral activity. JMJD1C-IN-1 targets tumor Treg cells without affecting systemic immune homeostasis.

HY-15221

Methylstat	Inhibitor	98.85%
Methylstat is a potent histone demethylases inhibitor. Methylstat shows anti-proliferative activity with low cytotoxicity. Methylstat induces apoptosis and cell cycle arrest at G0/G1 phase. Methylstat increases the expression of p53 and p21 protein levels. Methylstat inhibits angiogenesis induced by various cytokines. Methylstat can be used as a chemical probe for addressing its role in angiogenesis.

HY-139434

JMJD6-IN-1	Inhibitor	99.69%
JMJD6-IN-1 (Compound 1-3) is a JMJD6 inhibitor, with an inhibition rate of 82% at 10 μM. JMJD6-IN-1 inhibits MCF-7 and HCC4006 cell proliferation with IC₅₀s of 19.2 μM and 25.2 μM. JMJD6-IN-1 can be used for research of cancers.

HY-19333

OG-L002	Inhibitor	99.81%
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes.

HY-119397A

KDM5-C49 hydrochloride	Inhibitor	99.95%
KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC₅₀s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 hydrochloride can be used for the research of cancer.

HY-110130

RN-1 dihydrochloride	Inhibitor	99.13%
RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC₅₀ values of 0.51 μM and 2.785 μM respectively.

HY-103713A

Seclidemstat mesylate	Inhibitor	99.60%
Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (K_i=31 nM, IC₅₀=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma.

HY-114519

Helenalin acetate	Inhibitor	98.59%
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities.

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